Analysis of Ion Channel Genetic Mutations in Disease
Creative Bioarray focuses on bioinformatics technology, the development of advanced algorithms, and the establishment of various databases to provide clients with ion channel genetic mutation detection and analysis services. Our professional scientific services will help you obtain reliable experimental data and accelerate the discovery of new targets for the treatment of multiple channelopathies.
Introduction
Gene mutations involving ion channel subunits or proteins can lead to a variety of diseases including the nervous system, cardiovascular system, and endocrine system diseases. Therefore, ion channels are one of the most important drug targets and also one of the indicators for drug safety evaluation. Artificial intelligence technology in bioinformatics provides a powerful tool for understanding gene mutations in ion channels and is expected to promote the process of drug discovery to a large extent.
Artificial intelligence technology can be used to detect genetic variants of ion channels in a variety of diseases, including epilepsy, Alzheimer's disease, and more. In epilepsy, approximately one-third of patients are found to be ineffective against most of the antiepileptic treatments of drugs that have been identified so far that target ion channels. It has been reported that sequence variants that alter access to drug binding sites can be candidates for pharmacoresistant mechanisms. The variant profiles obtained by bioinformatics analysis provide the possibility for identifying drugs that are ineffective for various excitability disorders related to channel modulation to develop personalized treatments.
Fig. 1 Potassium channels involved in skeletal muscle myopathies. (Maggi, 2021)
Our Services
Our research team has made great progress in various bioinformatics technologies such as next-generation and whole-exome sequencing. We have the strength to use a variety of advanced technologies to provide clients with the detection of channel genetic mutations. Our services include but not limited to:
- We help clients obtain exonic single nucleotide polymorphism (SNP) profiles of the type, the relative burden, and the variation pattern in a large number of genes including ion channel candidates.
- We help clients compare SNP profiles between healthy/drug-unaffected individuals and individuals with neuron excitability disorders and provide detailed data analysis to assess personal genetic liability.
- We provide allele and genotype distribution analysis of ion channel candidates in case and control populations.
- We provide microarray meta-analysis of ion channel genes and help clients identify disease-specific candidate ion channels based on gene expression profiling.
- We provide correlation analysis of tumor grade and ion channel gene expression.
We provide the above analysis services to our clients in multiple research projects, including but not limited to:
- Detection of ion channel genetic variants in epilepsy.
- Detection of ion channel genetic variants in Alzheimer's disease.
- Detection of ion channel genetic variants in cancer, such as breast cancer.
Advantages
- Professional technical support
- Development of differentiated strategies for each client's specific scientific needs
- Detailed bioinformatics data analysis
Equipped with first-class experimental equipment and an excellent research team, Creative Bioarray has the strength to help clients detect gene mutations in various ion channel diseases, which helps to provide new targets for these diseases. If you are interested in our services, please feel free to contact us for more details.
Reference
- Maggi, L.; et al. Ion channel gene mutations causing skeletal muscle disorders: pathomechanisms and opportunities for therapy. Cells, 2021, 10(6): 1521.
