Analysis of Ion Channels in Native Tissues

Like other permeation pathways of biofilms, ion channels are essential to life because they generate action potentials and regulate synaptic transmission in neurons and muscle cells, underlie intracellular Ca²⁺ signaling, and contribute to separate charges across the plasma membrane. Gene defects or acute dysregulation of ion channel activity, trafficking, or degradation often contribute to severe channelopathies and pathologies.

Due to the heteromultimeric co-assembly of channel α-subunits with other β-subunits, other interacting subunits, and other modifications (such as glycosylation, alternative splicing of mRNA, and phosphorylation), the number of channels with different functions in natural tissues is further increased. There is a need to utilize multiple advanced techniques to understand the properties and functions of ion channels present in natural tissues to accelerate the development of drugs targeting ion channels.

Our Services

Researchers at Creative Bioarray are dedicated to providing clients with specialized services for the analysis of ion channels in native tissues, including neurons, glomeruli, myocardium, skeletal muscle, smooth muscle, and pulmonary epithelium. Our ion channel analysis involves biophysics, electrophysiology, molecular biology, and pharmacology, using techniques such as voltage clamp, patch clamp, immunohistochemistry, X-ray crystallography, fluoroscopy, and RT-PCR.

Analysis of Dendritic Ion Channels

We are committed to providing clients with professional scientific services and technical support in the research of dendritic ion channels, including recording, biophysical characterization, and functional analysis.

Analysis of Ion Channels in Erythrocytes

Our research team has established a variety of protocols of electrophysiological and non-electrophysiological methods to help clients directly or indirectly study ion channels in erythrocytes.

Analysis of Ion Channels in Glomeruli

We are committed to establishing new protocols to provide clients with ion channel analysis services in glomeruli, including single channel analysis and ratometric calcium concentration measurements.

Analysis of Ion Channels in Cardiomyocytes

We help clients analyze the biophysical properties and function of ion channels in cardiomyocytes using a variety of electrophysiological techniques and combined technologies.

Analysis of Ion Channels in Skeletal Muscle

We provide clients with analytical services of ion channels in skeletal muscle, including activity and expression detection of various ion channels that contribute to muscle and adjacent tissue function critical.

Analysis of Ion Channels in Smooth Muscle

We provide clients with comprehensive analysis services for ion channels in various smooth muscles, such as vascular smooth muscle, airway smooth muscle, and pulmonary artery smooth muscle.

Analysis of Ion Channels in Pulmonary Epithelia

We provide clients with analysis and characterization services of ion channels in the lung, providing valuable information for studying the ion transport properties of airway epithelium and alveolar epithelium.

Advantages

• Scientists with rich experience in the field of ion channel analysis
• Advanced technology platform for cell-based ion channel detection
• Flexible scientific services to quickly adapt to research developments

Creative Bioarray provides clients with unparalleled research design and scientific services in the analysis of ion channels in native tissues. Our professional data analysis and report writing ability will bring you a satisfactory service experience. If you are interested in our services, please feel free to contact us for more details.