Development of Channelopathy Models
Channelopathies involve muscles, nerves, heart, kidneys, endocrine, and other organs and systems, posing a great threat to human health. Therefore, it is necessary to strengthen the multidisciplinary comprehensive research of molecular biology, biophysics, genetics, pharmacology, etc., and establish stable channelopathy models for the efficacy study of lead candidates, which will help to explain the relationship between ion channel gene defects, functional changes, and diseases, and thus open new avenues for the prevention, diagnosis, and treatment of channelopathies.
Creative Bioarray provides clients around the world with professional modeling services for a variety of channelopathies, including cardiovascular channelopathies, renal channelopathies, metabolic channelopathies, and neural channelopathies. The development of disease models helps clients to further study the mechanism of disease occurrence and development, as well as potential treatment options. Our experienced research team helps clients develop comprehensive animal disease models based on diverse organ systems, which allows the testing of promising compounds and optimization of lead candidates.
Fig. 1 Disease models recapitulating human channelopathies and therapeutics. (Kabra, 2020)
Channelopathy Modeling Services
Our specialized disease modeling services, combined with advanced electrophysiological characterization techniques, help further elucidate genetic variation in ion channel genes associated with diseases such as epilepsy, thereby accelerating the process of drug discovery. We will develop a detailed service agreement based on your program and needs to develop the channelopathy model you are interested in.
- Neurological channelopathies
- Epileptic syndromes
- Ataxia syndromes
- Familial hemiplegic migraine
- Pain syndromes and neuropathies
- Kidney channelopathies
- Bartter's syndrome
- Dent's disease
- EAST/SeSAME Syndrome
- Heart channelopathies
- Long QT and Short QT syndromes
- Brugada syndromes
- Catecholaminergic polymorphic ventricular tachycardia
- Pancreas channelopathies
- Familial Congenital hyperinsulinism and neonatal diabetes mellitus
- Skeletal muscle channelopathies
- Nondystrophic myotonias
- Periodic paralysis
We offer a variety of channelopathy models designed to help clients screen and understand drug properties. Additionally, animals used for modeling were provided by certified animal suppliers.
Development of Relevant iPSC-based Models of Channelopathies
Induced pluripotent stem cells (iPSCs) hold great promise in disease modeling due to their potentially limitless source, offering the ability to differentiate and study affected human cells in the absence of other animal models. Our research team is dedicated to deriving and characterizing patient-specific models of inherited channelopathies using iPSC technology.
Applications
- Study on pathophysiological mechanisms of channelopathies
- Testing of promising compounds
- Optimization of lead candidates
Creative Bioarray has accumulated many years of experience in developing various models of channelopathies. Our research teams with outstanding pharmacology and pharmacodynamics backgrounds and specialized cell culture solutions allow you to generate and study complex models of channelopathies. If you are interested in our services, please contact us for technical support. Our scientists are pleased to help you determine the channelopathies model best suited for your research of interest.
Reference
- Kabra, M.; Pattnaik, B. R. Sensing through non-sensing ocular ion channels. International Journal of Molecular Sciences, 2020, 21(18): 6925.
