Identification of Ion Channel Targets and Modulators
For decades, the research in the field of ion channels has greatly deepened people's understanding of the physiological functions of various systems of the organism, especially in the basic research of ion channels in the function of the nervous system. Interventions targeting ion channels have also become a research hotspot, and many results have been successfully applied to clinical treatment.
Creative Bioarray focuses on ion channels related to major diseases of the nervous system, establishes an ion channel drug research and development platform, promotes research on new mechanisms and functions of ion channels, discovers new ion channels, develops new modulators, and develops new drugs targeting ion channels. We have built specialized cell chambers and detection platforms, including manual patch clamp systems and fluorescence imaging systems, and are equipped with rapid programmable pressure drug delivery systems. Our perfect detection system has laid a solid foundation for the company's project target confirmation, efficient screening of active compounds, and in vitro safety evaluation.
Fig. 1 Ion channels in clinical development from the ligand and voltage-gated families, broken down by decade and ion channel subfamily.
(Bagal, 2013)
Our Services
- Prediction of Potential Drug Targets From Ion Channels
We are committed to providing clients with ion channel drug target prediction services by using a variety of experimental and computational tools, such as the prediction of potential drug targets based on SVM. - Validation of Ion Channel Targets
We provide clients with comprehensive services for drug development targeting ion channels, including identification and verification of ion channel targets, to help them determine the most promising drug discovery targets. - Identification of Ion Channel Modulators
We provide clients with identification and characterization services of ion channel modulators by combining high-throughput analysis technology with classic drug development technology. - Structure-Activity Relationship Analysis of Channel Modulators
We provide clients with structure-activity relationship analysis of channel modulators to help them rationally design bioactive molecules and accelerate research and development of ion channel drugs. - Optimization of Channel Modulators
We help clients evaluate ion channel modulators entering the lead optimization phase and develop unique strategies to expedite the optimization of these compounds and minimize the number of assays required.
Why Choose Creative Bioarray?
- Expert team with rich industry experience—our excellent research team has rich cooperation experience with many top pharmaceutical and biotechnology companies in the world.
- Outstanding technology and achievements—we use solutions from the entire industry and use cutting-edge technology in your ion channel drug discovery.
- Efficient, flexible, high-quality one-stop solutions—we are happy to carry out phased projects and plan key milestones and deliverables in advance.
Creative Bioarray has a high-level ion channel pharmacology team, including not only well-known ion channel experts but also doctors and masters with ion channel research backgrounds. Our platform technology and talented team are at the international first-class level. We develop solutions for our clients at all stages of ion channel drug discovery to improve the probability of successful drug development. If you are interested in our scientific services, please contact us for more details.
Reference
- Bagal S K, Brown A D, Cox P J, et al. Ion channels as therapeutic targets: a drug discovery perspective[J]. Journal of medicinal chemistry, 2013, 56(3): 593-624.
