Ion Channel Genetic-Level Analysis

Ion channels are a complete class of pore-forming membrane proteins present in the membranes of all cells. Various types of ion channels such as sodium, potassium, and calcium channels have been shown to be involved in various biological processes and play key roles. The normal structure and function of cellular ion channels are the basis for sustaining life processes. Due to the widespread distribution and biological importance of ion channels in organisms, defects in their expression and functional activity can lead to a variety of diseases. The study of ion channels has been a key area of focus for researchers over the past few decades and significant research progress has been made in this field. The study of ion channel genes is the basis for an in-depth understanding of the biological functions of ion channels. In recent years, the development of some efficient tools for large-scale genetic analysis has provided new insights into the regulatory pathways of ion channel genes involved in various processes.

Our Services

Researchers at Creative Bioarray are committed to providing clients with comprehensive customized services for ion channel gene analysis, including cloning of ion channel genes, splice isoform profiling of ion channels, generation of stable expression systems for ion channels, and production and purification of recombinant ion channels. Our scientific team's proven expertise and flexible service portfolio in the cloning and heterologous expression of ion channel genes enable us to meet the diverse scientific needs of our clients.

• Cloning of Ion Channel Genes

We provide clients with cloning services for ion channel genes, especially genes encoding ion channels that play vital roles in nociceptive processing.

• Splice Isoform Profiling of Ion Channels

We provide clients with long-read transcript profiling of ion channel splice isoforms using mRNA sequencing methods that combine long-read nanopore sequencing technology with PCR targeting.

• Development of Ion Channels Expression Systems

We are dedicated to providing clients with development services of expression systems for ion channels using recombinant DNA technology.

• Recombinant Production and Purification of Ion Channels

We are committed to helping clients achieve efficient, fast, and flexible plasmid construction and recombinant production of ion channels using the cloning technology of homologous recombination in Saccharomyces cerevisiae.

Advantages

• Leading capability in ion channel research
• One-stop services include gene cloning, development of expression systems, and ion channel analysis
• Multiple stable expression systems for ion channels
• Experienced technicians and professional technical platform

Drug development based on ion channels is a long and complex process. Creative Bioarray is committed to providing clients with comprehensive ion channel gene analysis services to accelerate early drug discovery programs. If you are interested in our services, please feel free to contact us and we will provide you with professional technical consulting services and flexible industry solutions.

Reference

1. Harrell, M. D. et al. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiological genomics, 2007, 28(3): 273-283.