Ion Channel Screening
Creative Bioarray is committed to providing one-stop solutions for high-throughput screening of ion channel drugs by integrating virtual screening and experimental screening, accelerating new drug discovery. We have a first-class ion channel screening platform, as well as a high-throughput automated patch clamp system and a fluorescence-based high-throughput ion channel detection system, allowing us to provide clients with different types of ion channel screening and analysis services to meet the needs for fast and accurate results in the process of drug research and development.
Introduction
Despite their proven physiological and pathological importance, ion channels as drug targets are largely underutilized. As far as the drug discovery process is concerned, selecting the most appropriate ion channel for drug discovery research is often the first critical step on the road to success. However, the lag in screening technology has resulted in a lack of throughput and quality data required for medicinal chemistry. Currently, several new technologies are being developed to overcome previous technical challenges, which can be applied in the early stages of ion channel discovery and allow the discovery of new therapeutic agents.
Fig. 1 Biochemical classes of drug targets of current therapies. (Treherne, 2006)
Ion Channel Screening Capabilities
- Provide large-scale high-throughput screening to eliminate repetitive studies and long cascading cycles with electrophysiological approaches.
- Obtain detailed pharmacological and biophysical information using conventional platforms and automated electrophysiology platforms.
- Perform fluorescence-based screening of a large number of compounds.
- Capture large-scale transient expression, allowing hundreds of millions of cells per transfection.
Our Services
Researchers at Creative Bioarray have established multiple high-throughput screening protocols for a variety of ion channels to provide clients with accurate ion channel screening data. Our services include but not limited to:
- Ion Channel Flux Assays
We are committed to providing one-stop solutions for high-throughput screening of ion channels by ion flux assays, accelerating the process of target channel screening and drug discovery. - Ion Channel Binding Assays
We are committed to providing clients with best-in-class ion channel binding assay services to help them determine the interaction and affinity of specific compounds with ion channels of interest. - Screening of Cardiac Ion Channels
We provide clients with high-quality ion channel screening, cardiac safety screening assays, and iPSC-derived cardiomyocyte screening services. - Screening of Neuronal Ion Channels
We focus on the latest advances in electrophysiological techniques for screening ion channel function and regulation to provide clients with ion channel screening services relevant to neuroscience. - lon Channel Cell Line Development
Screening Process
Screening process at Creative Bioarray
Service Advantages
- Available with multiple assay techniques, including QPatch, Qube, and Patchliner automated electrophysiology, and manual patch clamp electrophysiology.
- Available with screening services for a variety of ion channels: chloride channels, sodium channels, potassium channels, calcium channels, TRP channels, etc.
- Over 10 years of experience in the field of ion channel screening.
- Wide range of screening and low screening costs.
- Fast turnaround time and highly customizable services.
Creative Bioarray is committed to providing clients with different types of ion channel screening services. Our extensive expertise in ion channel screening and drug discovery enables us to provide you with reliable and high-quality data to accelerate the process of drug discovery. If you are interested in our services, please feel free to contact us for more details.
Reference
- Treherne, J. M. Exploiting high-throughput ion channel screening technologies in integrated drug discovery. Current pharmaceutical design, 2006, 12(4): 397-406.
