Leading the Way for New Drug Discovery
Ion channels are key components in a variety of biological processes involving rapid cellular changes and have broad therapeutic applicability in multiple therapeutic areas including oncology, neurological diseases, metabolic diseases, pain, infectious diseases, and more. As a novel drug discovery platform, Creative Bioarray's ion channel technology platform leverages a combination of proprietary expertise in bioassays, medicinal chemistry, biophysics, and computational chemistry applications to help clients analyze the structure and function of a variety of ion channels and transporters. We provide partners in the pharmaceutical industry with a technology platform to develop candidate therapeutics targeting ion channels to accelerate drug development programs. Our talented team is dedicated to understanding your unique testing and reporting needs to quickly determine the right solution for your project.
Advanced Ion Channel Technology — Platform Assay Flexibility via Hightech
In the past 20 years, researchers at Creative Bioarray have made a lot of contributions and achieved great achievements in the field of ion channel research and screening. We provide a variety of cutting-edge technologies for ion channel analysis, structural and functional characterization, mechanism of action studies, and screening to support our partners in their discovery of novel ion channel therapies.
Patch Clamp Electrophysiology Platform
Patch-clamp electrophysiology has emerged as a versatile electrophysiological tool for understanding ion channel behavior due to the extreme precision and flexibility it offers. Our patch clamp technique is applicable to all cells expressing ion channels, such as neurons, myofibers, cardiomyocytes, and oocytes that overexpress individual ion channels. These techniques allow researchers to understand how ion channels behave in normal and disease states, and how different drugs, ions, or other analytes affect these characteristics.
Our patch clamp system can record almost all electrophysiological signals, including:
- Action potential
- Electro-oculogram (EOG)
- Excitatory postsynaptic potentials (EPSPs)
- Inhibitory postsynaptic potentials (IPSPs)
- Long-term potentiation (LTP)
- Fluorescence staining ratio
- Synaptic network information
- Electromyography (EMG)
- Excitatory postsynaptic currents (EPSCs)
- Inhibitory postsynaptic currents (IPSCs)
- Tiny excitatory potential (Minis)
- Long-term depression(LTD)
- Peak potential string
Automated Patch Clamp (APC) Platform
We offer multiple high-throughput screening technologies for a variety of ion channels including ligand-binding assays, flux-based assays, fluorescence-based assays, and automated electrophysiological assays to meet a wide range of clients' extensive scientific research needs. Our scientists have developed a variety of automated patch clamp (APC) technology platforms over the past decade, including lipid bilayer recording, glass pipette electrode recording, Xenopus Oocytes two-electrode recording, and chip- or plate-based planar recording techniques. For different ion channel subclasses, we provide clients with the best high-throughput screening method based on ion selectivity, channel activation kinetics, and whether ligand is required.
Key Features
- Giga-ohm sealed high quality recordings
- >85% success rates routinely achieved
- High-throughput ion channel recordings without sacrificing performance and data quality
- High-throughput automation for flow-dependent analysis
- Very low drug consumption and fast drug exchange
- High throughput continuous flow APC system
- Powerful, intuitive software setup and efficient data processing and analysis
Industry-Leading Flexibility and Performance for High-Throughput Patch-Clamp Assays
Our first-class technology platform allows us to provide comprehensive solutions for your research in ion channel related fields.
Ion Channel Analysis
Our technology platform allows the evaluation of the current or voltage in the membrane related to the activity of ion channels by using ultra sensitive amplifiers and high-quality data acquisition systems for real-time direct measurements to evaluate the results.
Electrophysiology
Our technology platform allows us to provide clients with a wide range of electrophysiological research, including analyzing the behavior of single ion channels in a cell membrane, analyzing the whole cell changes of cell membrane potential, and analyzing the larger scale changes of field potential in brain slices in vitro or brain regions in vivo.
Cellular Pathway Analysis
Ion channels are involved in many cellular pathways. We provide technical support for clients to study the function of ion channels in response to membrane potential changes or the presence or absence of other molecules to clarify how ion channels participate in normal and abnormal biological processes, such as disease status and neuronal communication.
Disease Research
Ion channels play a role in many diseases, such as hypertension, arrhythmia and neuromuscular diseases. We provide technical support for clients to study the exact role of ion channels in specific diseases, which helps scientists find a way to affect ion channels, thereby changing the course of the disease.
Drug Mechanism Research
Our channel recordings can help clients analyze the possible effects of various concentrations of drugs applied at different times and locations (inside or outside the membrane) on channel functions, which is helpful to understand the molecular mechanism of those drugs that selectively act on ion channels.
Drug Discovery
Our researchers are committed to promoting the combination of APC technologies and high-throughput virtual screening technologies targeting ion channels to shorten the process of drug discovery. Our preclinical drug development scientists provide the integrated strategy according to your requirements.
