Synthesis of Ion Channels

Creative Bioarray is committed to helping clients synthesize ion channels through a variety of strategies to simulate the structure and function (transport ions selectively and rectification) of ion channels on cell membranes in organisms, providing useful information for in-depth research on ion channel diseases and the development of specific therapeutic drugs.

Background

The rapid development of electrophysiology, structural biology, and molecular biology technology has greatly accelerated the understanding of the structure and properties of ion channels, but the mechanism of action is still not clearly elucidated. Ion channels, such as K⁺, Ca²⁺, Cl^-, and Na⁺, are closely related to the occurrence and development of many diseases, and are also the therapeutic targets of these diseases. Therefore, an in-depth understanding of the structure and function of ion channels is of great significance for the in-depth study of the pathological mechanism of certain diseases and the discovery of specific therapeutic drugs.

Unlike natural ion channels, synthetic ion channels can be simple molecules but still possess the functional groups and molecular dimensions required for channel activity. Therefore, synthetic ion channels can be used as models to simplify the study of ion channel phenomena. In addition, synthetic ion channels may find applications in drug delivery in vivo and sensors, which makes the research of artificial ion channels attract more and more researchers' attention, and new research results continue to emerge. At present, many artificial ion channels with good biological activity and antibacterial and anticancer functions have been synthesized.

Fig. 1 Synthetic channel monomers with inherent dipoles and schematic representation for the formation of voltage responsive channels. (Chen, 2018)

Our Services

Our research team is dedicated to helping clients build various synthetic ion channels through precise structural design. Our services include but not limited to:

• Development of synthetic ion channels with controllable transport behavior, including voltage-gated synthetic channel, ligand-gated synthetic channel, light-gated synthetic channel, mechano-sensitive synthetic channel, and rectifying synthetic channel.
• Development of building blocks, including but not limited to:
• Design, synthesis, and characterization of biscyclophane.
• Design and synthesis of non-macrocyclic compounds and evaluation of their channel-forming properties.
• Solid-phase synthesis for ion channels With the available building blocks and techniques.
• Optimization of the Chemistry.
  We provide three methods to optimize chemical reactions to meet the scientific research needs of our clients.
• Improvement of the purity of the building blocks.
• Optimization of the deprotecting and cleaving reaction conditions.
• Full analyses on all the intermediates involved, including GPC chromatography, NMR, and MALDI MS.

Applications

• Study on complex functions of channel proteins
• Development of sensors, molecular devices, and separation materials
• Development of treatments for channelopathies

In recent years, Creative Bioarray has focused on the field of synthetic ion channels to increase the variety and diversity of artificial ion channels. These biomimetic ion channels have broad application prospects in analytical chemistry, biomedicine, and life sciences. If you need ion channel synthesis services, please feel free to contact us for more information.

Reference

1. Chen, J. Y.; Hou, J. L. Controllable synthetic ion channels. Organic Chemistry Frontiers, 2018, 5(10): 1728-1736.