Analysis of Multimodal-Gated Ion Channels

Multimodal-gated ion channels modulate various cellular functions in response to multiple physiological stimuli. Creative Bioarray is committed to providing clients with professional and detailed structural and functional characterization services of multimodal-gated ion channels, providing valuable information for understanding the mechanisms involved in multimodal channel activation.

Background

Ion channels are composed of special proteins produced by cells and play an important role in regulating osmotic pressure inside and outside cells as well as maintaining cell membrane potential. The ability of cells to regulate the rate at which substances enter and exit the cell through the opening and closing of ion channels to maintain normal cellular function. Different classes of ion channels can respond to different physiological stimuli, such as voltage-gated and ligand-gated ion channels.

Cells of multicellular organisms experience a variety of mechanical stimuli, such as the direct mechanical effects of pulling and stretching and changes in hydrostatic and osmotic pressure. Multimodal ion channels can integrate diverse cellular signals to mediate more precise and flexible physiological responses, resulting in changes in gene expression, cell shape, and cytoskeletal organization. The transient receptor potential (TRP) vanilloid channels are typical multimodal cation channels. Members of the TRP superfamily can transduce chemical, mechanical, thermal, painful, and osmotic stimuli into Ca²⁺ fluxes and are important in the regulation of neuronal physiology. Detailed characterization of these ion channels can help to understand the disruption caused by disease-causing genetic mutations.

Fig. 1 TRPV1 and TRPV4 modulate Ca²⁺ homeostasis in subsets of retinal ganglion cells. (Lakk, 2018)

Our Services

Our researchers are dedicated to assisting clients in the detailed characterization of a variety of multimodal-gated ion channels to advance understanding of the structure, biophysics, and physiology of these ion channels. Our services include but not limited to:

• Structural Characterization of TRP Channels
  We are committed to providing clients with rich structural information about TRP ion channels using a variety of techniques including EM, X-ray crystallography, and NMR spectroscopy.
• Functional Characterization of TRP Channels
  We are committed to providing clients with detailed functional characterization services of TRP channels, aiming at a deeper understanding of the structure-function relationship in TRP channels.
• Analysis of Connexins and Pannexins
  We are committed to providing clients with high-quality connexin and pannexins analysis services and obtaining data describing the characteristics of the connexin family and junctional channels formed by different connexins.

Advantages

• Effective interactions and unsurpassed flexibility
• Solutions tailored to your needs
• Robust and reproducible dat
• Short turnaround

As a service provider in the field of ion channels, Creative Bioarray has the strength to provide clients with high-quality multimodal-gated ion channel characterization services. If you are interested in our services, please feel free to contact us. Our experienced scientists will work with you to design your research project to solve your scientific question and fit your budget.

Reference

1. Lakk, M.; et al. Polymodal TRPV1 and TRPV4 sensors colocalize but do not functionally interact in a subpopulation of mouse retinal ganglion cells. Frontiers in cellular neuroscience, 2018, 12: 353.