Analysis of the Relationship Between Ion Channels and Diseases
Ion channels are the material basis for the electrical activity of nerve and muscle cells. With the development of molecular biology, genetics, biophysics, and computational biology, people have a deeper understanding of the molecular structure and characteristics of ion channels, and found that ion channels are related to the occurrence and development of many diseases. Ion channel changes in pathologies refer to changes in the number, function or even structure of one or several ion channels caused by a disease or drug, leading to the occurrence or correction of some pathophysiological changes in the body.
In this post-genomic era, the genes encoding most ion channels have been deciphered, and the comprehensive exploration of channel proteins has become a new frontier in biological and biomedical research. Combined with bioinformatics technology, elucidation of the relationship between the structure and function of ion channels, and the relationship between ion channel gene mutations and diseases will be gradually realized.
Our Services
Our researchers are committed to using advanced technologies in cell biology, physiology, and other fields as well as computational design strategies to provide clients with the detection of ion channel genetic mutations in diseases and functional assessment of ion channel variants, providing useful information for understanding the relationship between ion channels and diseases.
Analysis of Ion Channel Genetic Mutations in Disease
Our research team focuses on bioinformatics technology, the development of advanced algorithms, and the establishment of various databases to provide clients with ion channel genetic mutation detection and analysis services.
Functional Evaluation of Disease-related Ion Channel Variants
We provide clients with functional evaluation of ion channel variants associated with channelopathies by combining highly efficient electroporation for heterologous expression of recombinant ion channels with automated planar patch clamp recording.
At present, the number of diseases related to ion channels that have been identified is increasing rapidly. It is very important to elucidate the molecular mechanism of channelopathies for the early diagnosis and treatment of these diseases. We help clients explore the correlation between various diseases and ion channels, including but not limited to:
| Heart Disease | Brain Disease | Kidney Disease | Lung Disease |
| Inherited long QT syndrome Drug-acquired long QT syndrome Brugada syndrome |
Episodic ataxia (EA) Spinocerebellar ataxia type 6 (SCA6) |
Bartter's syndrome Liddle's syndrome Polycystic kidney |
Cystic fibrosis (CF) |
Advantages
- Highly qualified experts with extensive experience
- Deliver detailed service reports and provide technical support
- High project success rate >90%
- Cost-efficient & fast turnaround
Creative Bioarray has a research team composed of experts in multiple scientific fields and advanced technology platforms. We have accumulated rich experience in the research of ion channels in health and disease and we are confident to provide you with professional scientific services and provide accurate and reliable scientific data in a short period of time, accelerating ion channel research and drug discovery. If you are interested in our services, please feel free to contact us for more details.
